Sjögren's disease & overlap diseases
Characterisation of airway disease associated with Sjögren disease
Authors' conclusion
Sjo-AD preferentially affects Sjo patients with higher biological activity. It is often characterised as a diffuse disease, affecting both proximal and distal airways, with a slow evolution over time and no progression to Sjo-ILD.
Study context
- Population
- Patients with SjD with or without airway disease, nine centresmatched controls
- Participants
- 31 vs 62
- Exposure
- SjD-associated airway disease vs SjD controls without pulmonary involvement
- Sjo-ADn = 31
- Sjo controlsn = 62reference
- Outcome
- Disease activity (ESSDAI), excluding pulmonary domain
Methodological detailsmulticentre, matched for age and disease duration, central CT review by a single thoracic radiologist
- Multicentre
- Matched for age and disease duration
- Central CT review by a single thoracic radiologist
Main finding
As reported in the abstract
Sjo-AD
7
Sjo controls
3.8
P < 0.05
Observational data: associations, not effects.
Further findings
Sjo-AD characteristics
- Multilobar
- 72%
- Signs of both bronchiectasis and bronchiolitis
- 60%
- Obstructive lung disease at Sjo-AD diagnosis
- 32%
Sjo-AD course
- Pulmonary function test (PFT) stable overall; follow-up, years
- 8.7±7
- Extended lesions on repeated CT
- 41%
- Time to repeated CT, years
- 6±3.2
- Patients developing Sjo-ILD
- 0
- Sjo-AD progression independent of global disease activity
Original publication
Characterisation of airway disease associated with Sjögren disease. RMD Open. Published 29 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →