The immune cell landscape analysed by imaging mass cytometry in the muscle of patients with inclusion body myositis associated or not with Sjögren’s disease
Authors' conclusion
Using IMC on muscle biopsies, IBM-SjD and sIBM patients share common histological features, but there are notable distinctions (more extensive infiltrate, high numbers of B cells and plasma cells in IBM-SjD).
Study context
- Population
- Formalin-fixed, paraffin-embedded muscle biopsies of patients with inclusion body myositis (IBM), six French expert centresmuscle samples analysed
- Participants
- 14 vs 7
- Comparison
- IBM associated with Sjögren's disease (SjD) vs sporadic IBM
- IBM-SjDn = 14
- sIBMn = 7reference
- Outcome
- Muscular inflammatory infiltrate composition
Methodological detailsmulticentre, exploratory, imaging mass cytometry (34 markers)
- Multicentre
- Exploratory
- Imaging mass cytometry (34 markers)
Main finding
As reported in the abstract
Muscle inflammatory infiltrate
- No statistically significant difference was encountered but some trends were pointed
- In both groups, main inflammatory cells were macrophages and T cells
Further findings
| Outcome | IBM-SjD | sIBM |
|---|---|---|
| Inflammatory infiltrate surfaceNo statistically significant difference · median | 4.8% (IQR 1.4–8.6) | 1.6% (IQR 1.2–2.4) |
| Proportion of plasma cellsNo statistically significant difference | 14.7% (IQR 5.4–24.6) | 8.5% (IQR 4.6–9.8) |
| Proportion of B cellsNo statistically significant difference | 3.1% (IQR 0.4–5.6) | 0.5% (IQR 0.0–3.2) |
Original publication
The immune cell landscape analysed by imaging mass cytometry in the muscle of patients with inclusion body myositis associated or not with Sjögren’s disease. Rheumatology (Oxford). Published 10 January 2026. doi:10.
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