Incident rheumatoid arthritis in patients living in Turkey and in Denmark: a comparative clinical, genetic, and serological study
Authors' conclusion
This study substantiates the north-south gradient hypothesis, highlighting that new-onset RA patients in Denmark tend to experience an older age of onset and more severe disease activity than their Turkish counterparts.
Study context
- Population
- Treatment-naïve, new-onset rheumatoid arthritis (RA) patients meeting the 2010 ACR/EULAR criteria in Denmark and Turkey
- Participants
- 223 participants
- Exposure
- Danish vs Turkish treatment-naïve, new-onset RA patients
- Danishn = 109
- Turkishn = 114reference
- Outcome
- Age at onset
Methodological detailsprospective data collection, 2010 ACR/EULAR criteria, genetic comparison with normal controls
- Prospective data collection
- 2010 ACR/EULAR criteria
- Genetic comparison with normal controls
Main finding
As reported in the abstract
Danish
60
median · years
Turkish
51
years
P = 0.0007
Observational data: associations, not effects.
Further findings
Swollen and tender joints; DAS28-CRP
- Danish cohort had significantly more swollen and tender joints, resulting in higher DAS28-CRP
SE alleles in patients and controls
- Danish patients and controls had more RA risk-enhancing (S2 + S3P) and fewer risk-protective (S1 + S3D) alleles than Turkish patients and controls
Original publication
Incident rheumatoid arthritis in patients living in Turkey and in Denmark: a comparative clinical, genetic, and serological study. Scand J Rheumatol. Published 25 November 2024. doi:10.
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