Vagotomy and the incidence of rheumatoid arthritis and osteoarthritis: a Danish register-based study
Authors' conclusion
Truncal vagotomy was associated with an increased incidence of RA; this association was not observed with superselective vagotomy. No association with either form of vagotomy was seen with OA.
Study context
- Population
- Patients in Denmark who underwent truncal or superselective vagotomy, 1977–1995, and matched general-population comparatorsmatched cohort
- Participants
- 2,260 / 22,610 / 3,810 / 38,090
- Exposure
- Truncal or superselective vagotomy vs matched general-population comparators
- Truncal vagotomyn = 2,260
- Truncal comparatorsn = 22,610reference
- Superselective vagotomyn = 3,810
- Superselective comparatorsn = 38,090reference
- Outcome
- Incident rheumatoid arthritis (RA) or OA
Methodological detailsnationwide health registries, matched 10:1 on birth year, sex, and calendar year, Cox proportional hazards models
- Nationwide health registries
- Matched 10:1 on birth year, sex, and calendar year
- Cox proportional hazards models
Main finding
As reported in the abstract
Incident RA
Adjusted hazard ratio (95% CI)
Truncal vagotomyvs Truncal comparators
2.62(1.47–4.67)
Superselective vagotomyvs Superselective comparators
1.05(0.51–2.17)
Observational data: associations, not effects.
Further findings
Incident osteoarthritis (OA)
- Risk of OA not significantly different for either vagotomy cohort vs comparison cohorts
Original publication
Vagotomy and the incidence of rheumatoid arthritis and osteoarthritis: a Danish register-based study. Arthritis Res Ther. Published 16 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →