Lupus & antiphospholipid syndrome
Incidence, Prevalence, and Mortality of Lupus Nephritis: A Population‐Based Study Over Four Decades Using the Lupus Midwest Network
Authors' conclusion
The incidence and prevalence of LN in this area increased in the last 4 decades. LN patients have poor outcomes, with high rates of ESRD and mortality rates 6 times that of the general population.
Study context
- Population
- Patients with incident lupus nephritis (LN) 1976–2018 in Olmsted County, Minnesota (1976–2009) and an 8-county region in southeast Minnesota (2010–2018)76% female
- Participants
- 72 patients
- Outcome
- Age- and sex-specific incidence rates and point prevalence of LN over 4 decades
Methodological detailsLupus Midwest Network, incidence and prevalence adjusted to the projected 2000 US population
- Lupus Midwest Network
- Incidence and prevalence adjusted to the projected 2000 US population
Main finding
As reported in the abstract
Average annual LN incidence per 100,000 population, 1976–2018
Average annual LN incidence per 100,000
1.0
95% CI 0.8–1.3
Overall incidence per 100,000, 1976-1989 to 2000-2018 (increase not statistically significant)
0.7 to 1.3
Estimated LN prevalence per 100,000, 1985 to 2015
16.8 to 21.2
Observational data: associations, not effects.
Further findings
| Outcome | SMR (95% CI) |
|---|---|
| Mortality vs general population (SMR)No improvement in the mortality gap in the last 4 decades | 6.33 (3.81–9.89) |
Survival and end-stage renal disease (ESRD) at 10 years
- Survival
- 70%
- Patients with ESRD
- 13%
Original publication
Incidence, Prevalence, and Mortality of Lupus Nephritis: A Population‐Based Study Over Four Decades Using the Lupus Midwest Network. Arthritis Rheumatol. Published 30 January 2023. doi:10.
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