Spondyloarthritis & psoriatic arthritis
Incidence and predictors of primary failure of targeted therapy in patients with Psoriatic Arthritis
Authors' conclusion
Primary failure of targeted DMARDs is common in PsA and may be influenced by socioeconomic and disease-related features.
Study context
- Population
- Patients with PsA on targeted DMARDs (biologic or synthetic) in a prospective observational cohort
- Participants
- 591 patients
- Exposure
- Primary failure vs responders and patients discontinuing for reasons not related to effectiveness
- Primary failuren = 209
- Outcome
- Incidence of primary failure of targeted DMARDs and associated factors
- Follow-up
- First year of therapy
Methodological detailsobservational, multivariable multinomial logistic regression adjusted for calendar time
- Observational
- Multivariable multinomial logistic regression adjusted for calendar time
Main finding
As reported in the abstract
Incidence of primary failure of targeted DMARDs; multivariable predictors (adjusted for calendar time)
Primary failure
35.4 %
209
Odds ratio (95 % CI)
Higher BMI
1.04(1.01–1.08)
Higher educational attainment
0.45(0.26–0.78)
SJC ≥5 at baseline
0.45(0.25–0.80)
Higher damaged joint count
0.96(0.93–0.995)
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Incidence and predictors of primary failure of targeted therapy in patients with Psoriatic Arthritis. Semin Arthritis Rheum. Published 27 October 2025. doi:10.
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