Lupus & antiphospholipid syndrome
In silico analysis highlights elevation of epithelial-to-mesenchymal transition characteristics in non-responding lupus nephritis patients
Authors' conclusion
This study suggests that the non-responder group may exhibit enhanced EMT features, particularly involving the upregulation of COL3A1, TNC, and PDGFRA in the tubulointerstitial region.
Study context
- Population
- LN patients (tubulointerstitial RNA-sequencing) and non-response LN patients (single-cell RNA-sequencing), datasets from public databases
- Outcome
- Genes upregulated in non-responder LN
Methodological detailsin silico analysis, RNA-sequencing and single-cell RNA-sequencing of public datasets
- In silico analysis
- RNA-sequencing and single-cell RNA-sequencing of public datasets
Main finding
As reported in the abstract
- Increased epithelial-to-mesenchymal transition (EMT) signature in LN patients
- COL3A1, TNC and PDGFRA commonly upregulated in both general LN and non-responder LN patients
- These genes predominantly expressed in renal tubular epithelial cells (single-cell RNA-sequencing)
- COL3A1, TNC and PDGFRA significantly upregulated in tubulointerstitial regions in three additional independent LN datasets
Original publication
In silico analysis highlights elevation of epithelial-to-mesenchymal transition characteristics in non-responding lupus nephritis patients. Lupus. Published 1 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →