Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey
Authors' conclusion
Physical function is significantly impaired in IIMs compared with non-IIM AIRDs or HCs, even in patients with inactive disease.
Study context
- Population
- Respondents to the COVAD international self-reported e-survey on COVID-19 vaccine safety in autoimmune rheumatic diseases (AIRDs), April to August 2021
- Participants
- 1,057 / 3,635 / 3,981
- Exposure
- IIM vs non-IIM AIRDs vs healthy controls
- IIMn = 1,057
- Non-IIM AIRDn = 3,635
- Healthy controls (HCs)n = 3,981reference
- Outcome
- PROMIS PF-10a scores
Methodological detailsinternational, multicentre, patient-reported e-survey
- International
- Multicentre
- Patient-reported e-survey
Main finding
As reported in the abstract
PROMIS PF-10a score, predicted mean (binomial regression model)
IIM
36.3
predicted mean · 95% CI 35.5–37.1
Non-IIM AIRD
41.3
predicted mean · 95% CI 40.2–42.5
HCs
46.2
predicted mean · 95% CI 45.8–46.6
P < 0.001
Observational data: associations, not effects.
Further findings
Independent factors for lower Patient-Reported Outcome Measurement Information System (PROMIS) PF-10a scores in inactive disease (multivariable regression)
- Older age, female, longer disease duration, and a diagnosis of IBM or PM
Original publication
Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey. Rheumatology (Oxford). Published 3 August 2022. doi:10.
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