Evaluating the value of superoxide dismutase in anti-MDA5-positive dermatomyositis associated with interstitial lung disease
Authors' conclusion
In patients with anti-MDA5-positive DM, the low SOD level before treatment indicated the presence of oxidative stress in the disease; the serum SOD level was affected by anti-Ro-52 antibodies and ferritin; there is a close relationship between serum SOD level and ILD among patients with anti-MDA5-positive DM
Study context
- Population
- Hospitalized patients with anti-MDA5-positive DM with interstitial lung disease (ILD) and health check-up controls, single hospital
- Participants
- 94 vs 90
- Exposure
- Anti-MDA5-positive DM with ILD vs health check-up controls
- Anti-MDA5-positive DMn = 94
- Controln = 90reference
- Outcome
- Relationship between serum SOD and ILD
Main finding
As reported in the abstract
Serum SOD level
- Serum superoxide dismutase (SOD) significantly lower in anti-MDA5-positive DM than controls
- SOD significantly lower with both anti-MDA5 and anti-Ro-52 antibodies than with anti-MDA5 only, before treatment
- SOD significantly lower in higher vs lower serum ferritin group, before treatment
- After treatment, SOD decreased with ILD exacerbation and increased with alleviated ILD
- SOD significantly lower in death than survival group, before treatment
Observational data: associations, not effects.
Original publication
Evaluating the value of superoxide dismutase in anti-MDA5-positive dermatomyositis associated with interstitial lung disease. Rheumatology (Oxford). Published 22 July 2022. doi:10.
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