The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset
Authors' conclusion
Patients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.
Study context
- Population
- COVAD-2 survey respondents with IIM, other AIRDs, and healthy controls
- Participants
- 1,558 / 4,591 / 3,652
- Exposure
- IIM vs other autoimmune rheumatic diseases vs healthy controls
- Idiopathic inflammatory myopathies (IIMs)n = 1,558
- Other autoimmune rheumatic diseases (oAIRDs)n = 4,591reference
- Healthy controls (HCs)n = 3,652reference
- Outcome
- Prevalence of comorbidities, basic multimorbidity (≥2 non-rheumatic chronic conditions) and complex multimorbidity (≥3 non-rheumatic chronic conditions affecting ≥3 organ systems)
Methodological detailsself-reported survey (COVAD-2), hierarchical clustering on principal components
- Self-reported survey (COVAD-2)
- Hierarchical clustering on principal components
Main finding
As reported in the abstract
Comorbidity burden in IIMs
- IIMs vs oAIRDs · comorbidities
- OR 1.62; P < 0.01
- IIMs vs HCs · comorbidities
- OR 2.95; P < 0.01
- IIMs vs oAIRDs · basic multimorbidity
- OR 1.66; P < 0.01
- IIMs vs HCs · basic multimorbidity
- OR 3.52; P < 0.01
- IIMs vs oAIRDs · complex multimorbidity (vs AIRDs as printed)
- OR 1.69; P < 0.01
- IIMs vs HCs · complex multimorbidity
- OR 6.23; P < 0.01
- IIMs vs oAIRDs · mental health disorders
- OR 1.33; P < 0.01
- IIMs vs HCs · mental health disorders
- OR 2.63; P < 0.01
Observational data: associations, not effects.
Further findings
PROMIS scores in IIMs with comorbidities or mental health disorders
- Lower PROMIS Global Physical, Global Mental and Physical Function (SF10) scores, and higher fatigue (F4a) scores
- all P < 0.001
- PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), SF10a and F4a influenced by age, active disease, basic multimorbidity (BM) and mental health disorders (MHDs)
Cluster analysis in IIMs
- Distinct clusters identified according to comorbidities and PROMIS scores
- 4
Original publication
The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset. Rheumatology (Oxford). Published 25 September 2024. doi:10.
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