Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case–control study in the era of biologic drug therapies
Authors' conclusion
JIA patients were physically less active and had lower cardiorespiratory and neuromuscular fitness than their same aged controls with no JIA.
Study context
- Population
- Children and adolescents with juvenile idiopathic arthritis (JIA) aged 6.8–17.5 years and healthy matched controls, investigated in 2017–201973 JIA, 73 controls
- Participants
- 73 vs 73
- Exposure
- JIA patients vs healthy age- and sex-matched controls
- JIAn = 73
- Controlsn = 73reference
- Outcome
- Cardiorespiratory fitness (maximal ergospirometry) and neuromuscular fitness (speed, agility, balance and muscle strength tests)
Methodological detailscase–control, age- and sex-matched controls
- Case–control
- Age- and sex-matched controls
Main finding
As reported in the abstract
Maximal workload (Wmax/kg)
P < 0.01
Observational data: associations, not effects.
Further findings
Peak oxygen uptake (VO2peak/kg) · lower in JIA
P < 0.01
Daily activity · lower in JIA
P < 0.05
Sedentary time · higher in JIA
P < 0.05
- Shuttle-run, sit-up and standing long jump tests · lower in JIA
- P < 0.01
Association with disease activity
- Physical activity and cardiorespiratory or neuromuscular fitness not associated with disease activity
Original publication
Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case–control study in the era of biologic drug therapies. Pediatr Rheumatol Online J. Published 17 March 2023. doi:10.
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