Pediatric rheumatology

Cardiorespiratory fitness assessed with cardiopulmonary exercise testing in patients with juvenile idiopathic arthritis: a systematic review and meta-analysis

Rheumatology (Oxford)Published Systematic review and meta-analysis

Pooled result · VO2peakResult — go to the resultWeighted mean difference −5.95 ml/kg/min 95% CI −9.26 to −2.65

Authors' conclusion

VO2peak and other CPET variables were lower in patients with JIA compared with controls, indicating reduced CRF in the former.

Study context

Population
Children and adolescents with JIA vs healthy controls, studies using cardiopulmonary exercise testing (CPET)
Participants
538 children8 studies
Comparison
JIA vs healthy controls
Outcome
Peak oxygen uptake (VO2peak)
Methodological detailsNewcastle-Ottawa Scale quality assessment
  • Newcastle-Ottawa Scale quality assessment

Pooled result

VO2peak

Weighted mean difference

−5.95 ml/kg/min

95% CI −9.26 to −2.65

JIAvs Healthy controls
weighted mean difference −5.95 ml/kg/min (95% CI −9.26 to −2.65)

As reported in the abstract

Further pooled results

OutcomeSMD (95% CI)
Exercise duration−0.67 (−1.04 to −0.29)
OutcomeWeighted mean difference (%) (95% CI)
VO2peak (% predicted)−11.31 (−20.09 to −2.53)

Maximum heart rate

No significant differences

Original publication

Cardiorespiratory fitness assessed with cardiopulmonary exercise testing in patients with juvenile idiopathic arthritis: a systematic review and meta-analysis. Rheumatology (Oxford). Published 6 June 2023. doi:10.1093/rheumatology/kead272

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