Impact of anakinra use on clinical outcomes in children with moderate or severe multisystem inflammatory syndrome in children: a propensity score matched retrospective cohort study
Authors' conclusion
In patients with moderate to severe MIS-C, use of anakinra was associated with longer duration of hospital stay.
Study context
- Population
- Children admitted May 2020 to May 2021 with multisystem inflammatory syndrome in children (MIS-C) (CDC criteria) related to SARS-CoV-2, moderate or severe illness31 matched to 31
- Participants
- 138 children
- Exposure
- Anakinra use at any point during admission vs no anakinra
- Anakinran = 31
- No anakinran = 31reference
- Outcome
- Length of hospital stay
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
As reported in the abstract
- Hospital LOS longer in the anakinra group
- Propensity score matched
Observational data: associations, not effects.
Secondary outcomes
ICU LOS
- Not longer in the anakinra group
Duration of vasoactive support, fever resolution, CRP reduction, vasoactive inotropic score (VIS)
- No differences
Original publication
Impact of anakinra use on clinical outcomes in children with moderate or severe multisystem inflammatory syndrome in children: a propensity score matched retrospective cohort study. Pediatr Rheumatol Online J. Published 23 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →