Clinical outcomes and safety of anakinra in the treatment of multisystem inflammatory syndrome in children: a single center observational study
Authors' conclusion
Anakinra treatment, which was co-administered with IVIG primarily in patients with severe MIS-C, was associated with improvements in fever and cardiac function, and demonstrated a favorable side-effect profile.
Study context
- Population
- All multisystem inflammatory syndrome in children (MIS-C) patients diagnosed at a children's hospital, May 15 to November 15, 2020confirmed MIS-C
- Participants
- 46 patients
- Exposure
- Intravenous immunoglobulin (IVIG) plus anakinra vs IVIG monotherapy
- IVIG + anakinran = 32
- Outcome
- Fever and cardiac function in IVIG + anakinra (with or without CS)
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
As reported in the abstract
- IVIG + anakinra group enriched in CV shock phenotype
- p = 0.02
Observational data: associations, not effects.
Safety
- No significant adverse events were observed
Original publication
Clinical outcomes and safety of anakinra in the treatment of multisystem inflammatory syndrome in children: a single center observational study. Pediatr Rheumatol Online J. Published 31 July 2023. doi:10.
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