Spondyloarthritis & psoriatic arthritis
Impact of key manifestations of psoriatic arthritis on patient quality of life, functional status, and work productivity: Findings from a real-world study in the United States and Europe
Authors' conclusion
Most PsA manifestations were independently associated with worse general, and PsA-specific QoL, physical function, and work disability
Study context
- Population
- Psoriatic Arthritis (PsA) patients in the Adelphi 2018 PsA Disease-Specific Programme, United States and Europeanalysed
- Participants
- 2,222 patients
- Exposure
- PsA patients with vs without key manifestations
- Outcome
- Quality of life (QoL) (EQ-5D-5L, PsAID-12), physical function (HAQ-DI) and work disability (WPAI) by PsA manifestation
Methodological detailsmultinational, real-world, multivariate regression adjusting for potential confounders
- Multinational
- Real-world
- Multivariate regression adjusting for potential confounders
Main finding
As reported in the abstract
Mean EQ VAS score by manifestation
With vs without enthesitis
59.9 vs. 75.6
With vs without dactylitis
63.6 vs. 75.4
Peripheral joints: none / 1-2 / 3-6 / >6
82.5 / 74.1 / 74.2 / 65.0
Observational data: associations, not effects.
Further findings
Mean PsAID-12 score by manifestation
- With vs without enthesitis
- 4.39 vs. 2.34
- With vs without dactylitis
- 4.30 vs. 2.32
- Peripheral joints: none / 1-2 / 3-6 / >6
- 1.21 / 2.36 / 2.74 / 3.92
- BSA: none / >3-10% / >10%
- 1.49 / 2.96 / 3.43
- Significantly worse with manifestation
HAQ-DI and WPAI scores
- Similar patterns observed
Prevalence of manifestations
- Active psoriasis
- 77.0%
- Peripheral arthritis
- 64.4%
- Enthesitis
- 5.9%
- Dactylitis
- 6.8%
- IBP
- 10.2%
- Sacroiliitis
- 3.6%
Original publication
Impact of key manifestations of psoriatic arthritis on patient quality of life, functional status, and work productivity: Findings from a real-world study in the United States and Europe. Joint Bone Spine. Published 25 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →