Spondyloarthritis & psoriatic arthritis
All‐Cause and Cause‐Specific Mortality in Psoriatic Arthritis and Ankylosing Spondylitis: A Systematic Review and Meta‐Analysis
Authors' conclusion
This systematic review and meta-analysis showed a significantly increased risk of overall mortality in AS but not PsA. Cardiovascular-specific mortality was higher for both PsA and AS
Study context
- Population
- Studies reporting all-cause or cause-specific mortality in patients with psoriatic arthritis (PsA) and ankylosing spondylitis (AS) compared with the general population11 PsA, 7 AS, 1 both
- Participants
- 19 studies
- Comparison
- PsA and AS vs general population
- Outcome
- All-cause and cause-specific mortality
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
All-cause mortality
Each group vs general populationRelative risk (95% CI)
PsAn = 10 studies
1.12(0.96–1.30)
ASn = 6 studies
1.64(1.49–1.80)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| All-cause mortality by sex (subgroups)PsAvs General populationFemale | 1.19 (1.04–1.36) | |
| All-cause mortality by sex (subgroups)PsAvs General populationMale | 1.02 (0.66–1.59) | |
| All-cause mortality by sex (subgroups)ASvs General populationMale | 1.56 (1.43–1.71) | |
| All-cause mortality by sex (subgroups)ASvs General populationFemale | 1.85 (1.56–2.18) | |
| CVD mortalityPsAvs General population | 1.21 (1.06–1.38) | |
| CVD mortalityASvs General populationn = 3 studies | 1.35 (1.01–1.81) | |
| Respiratory, infection and cancer mortality (PsA)PsAvs General populationRespiratory | 3.37 (1.30–8.72) | |
| Respiratory, infection and cancer mortality (PsA)PsAvs General populationInfection | 2.43 (1.01–5.84) | |
| Respiratory, infection and cancer mortality (PsA)PsAvs General populationCancer | 1.01 (0.91–1.11) | |
| 0.10.31310Relative risk (log scale) |
Respiratory, infection and cancer mortality (PsA)
- AS studies did not report non-cardiovascular cause mortality
Original publication
All‐Cause and Cause‐Specific Mortality in Psoriatic Arthritis and Ankylosing Spondylitis: A Systematic Review and Meta‐Analysis. Arthritis Care Res (Hoboken). Published 19 January 2023. doi:10.
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