Sjögren's disease & overlap diseases
Immunological signatures in patients with Sjögren's disease: association with systemic disease activity at diagnosis
Authors' conclusion
The number and combination of SjD-related autoantibodies at diagnosis are robustly associated with systemic disease activity.
Study context
- Population
- Patients with Sjögren's disease (SjD) at diagnosis, Big Data Sjögren Project Consortium registry
- Exposure
- Immunological signatures
- Outcome
- Systemic disease activity (ESSDAI; simplified DAS: low, moderate, high) by immunological signature
- Follow-up
- At diagnosis
Methodological detailsinternational multicentre registry, demographic-adjusted ordinal models, sensitivity analysis by number of positive antibodies
- International multicentre registry
- Demographic-adjusted ordinal models
- Sensitivity analysis by number of positive antibodies
Main finding
As reported in the abstract
ESSDAI by signature
Fully seronegative
3.61
mean
ANA+/Ro+/La+/RF+
7.93
mean
ANA-/Ro-/La+/RF+
13.20
mean
- Each additional positive autoantibody: mean increase in EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) (points)
- 1.11
- Each additional positive autoantibody: increase in odds of higher Disease Activity Score (DAS) category
- 35%
Observational data: associations, not effects.
Further findings
Patients with at least one autoantibody · at diagnosis
- Proportion with ≥1 autoantibody
- over 94%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Immunological signatures in patients with Sjögren's disease: association with systemic disease activity at diagnosis. Clin Exp Rheumatol. Published 18 December 2025. doi:10.
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