Sjögren's disease & overlap diseases
A proteomic profile correlates with salivary gland inflammation and disease-associated antibodies in Sjögren’s disease
Authors' conclusion
We define a validated serum proteomic signature that reflects local glandular inflammation and correlates with genetic and serological features.
Study context
- Population
- Patients with primary Sjögren's disease (SjD) and controls; Swedish and Norwegian cohorts
- Participants
- 81 / 19 / 456 / 141 / 233 / 137
- Comparison
- SjD vs sicca or healthy controls
- SjD (paired gland/serum)n = 81
- Sicca controlsn = 19reference
- SjD (Swedish)n = 456
- Controls (Swedish)n = 141reference
- SjD (Norwegian)n = 233
- Controls (Norwegian)n = 137reference
- Outcome
- Serum and salivary gland proteomic biomarkers of SjD and their correlation with tissue inflammation
Methodological detailscase-control, discovery and replication cohorts, proximity extension assay, paired salivary gland extracts and serum
- Case-control, discovery and replication cohorts
- Proximity extension assay
- Paired salivary gland extracts and serum
Main finding
As reported in the abstract
Serum proteins associated with SjD
Proteins associated with SjD in serum, Swedish discovery cohort
27
Proteins validated in Norwegian replication cohort
16
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| 'Sjögren protein score': SjD vs healthy controls | Sjögren protein score AUC 0.888 · specificity 89% · sensitivity 76% |
Serological subgroups and human leukocute antigen (HLA)
- Levels of 16 validated proteins increased stepwise from antinuclear antibodies (ANA) negative (lowest) to anti-Ro/SSA and anti-La/SSB double-positive (highest); linked to HLA-DRB1*03 and DRB1*15
Extraglandular manifestations
- CXCL10, CXCL13, lysosome-associated membrane glycoprotein 3 and cytotoxic and regulatory T cell molecule correlated with extraglandular manifestations, particularly pulmonary involvement
Original publication
A proteomic profile correlates with salivary gland inflammation and disease-associated antibodies in Sjögren’s disease. Ann Rheum Dis. Published 12 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →