Vasculitis & polymyalgia rheumatica
Immunological and clinical predicators for venous thromboembolism in ANCA-associated vasculitis patients: elevated natural killer cells and cardiac involvement
Authors' conclusion
We identified the immunological and clinical risk factors for VTE in AAV, especially the elevated NK cells and cardiac involvement.
Study context
- Population
- Patients with antibody-associated vasculitis (AAV)validation cohort 45
- Participants
- 138 patients
- Exposure
- AAV patients with venous thromboembolism (VTE) vs without VTE
- Outcome
- Predictors of VTE in AAV and an AAV-VTE prediction model
Methodological detailsprediction model development and temporal validation, nomogram model
- Prediction model development and temporal validation
- Nomogram model
Main finding
As reported in the abstract
Each 10% increase in predicted probability associated with 1.99-fold increase in VTE odds
OR 1.990
95% CI 1.599–2.646P < 0.001
Observational data: associations, not effects.
Further findings
Characteristics of AAV patients with VTE
- Higher disease activity, more organ involvement, elevated natural killer (NK) cells and reduced Treg cells
Original publication
Immunological and clinical predicators for venous thromboembolism in ANCA-associated vasculitis patients: elevated natural killer cells and cardiac involvement. Arthritis Res Ther. Published 25 March 2026. doi:10.
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