Vasculitis & polymyalgia rheumatica
Prognosis and Long‐Term Outcome of Stenotic Large Vessel Involvement in Giant Cell Arteritis
Authors' conclusion
Stenotic LVV accounts for less than 10% of GCA and is associated with poor vascular prognosis.
Study context
- Population
- Patients with giant cell arteritis (GCA) with stenotic large vessel-vasculitis (LVV)198 (6.3%) with stenotic LVV
- Participants
- 3,149 patients
- Outcome
- Long-term outcome and prognosis (vascular complications) of GCA with stenotic LVV
Methodological detailsmulticentre, hierarchical clustering on principal components, logistic regression
- Multicentre
- Hierarchical clustering on principal components
- Logistic regression
Main finding
As reported in the abstract
Cumulative incidence of vascular complications
Cumulative incidence at 1 year
13.1%
95% CI 8.9–18.3
Cumulative incidence at 5 years
17.3%
95% CI 12.3–22.9
Cumulative incidence at 10 years
19.5%
95% CI 14.3–25.4
Observational data: associations, not effects.
Further findings
Factors associated with vascular complication (multivariate)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Age at diagnosis | 1.06 (1.03–1.10) | P = 0.0004 | |
| Vertebral involvement | 1.87 (1.03–3.40) | P = 0.039 | |
| 0.20.5125Hazard ratio (log scale) |
Vascular complications by type
- Stroke (main complication)
- 31%
- Limb ischemia
- 21%
- MI
- 4%
- Mesenteric ischemia
- 2%
Stenotic LVV localisation
- Subclavian artery
- 63%
- Carotid artery
- 58%
- Vertebral artery
- 37%
- Axillary artery
- 33%
- Femoral artery
- 30%
- Mesenteric arteries
- 13%
Hierarchical clustering
- Cluster 1 (n = 123; 62%): older patients, more arteritic anterior ischemic optic neuropathy (P = 0.04), vertebral artery stenosis, higher mortality rate (P < 0.044)
- Three clusters identified
Original publication
Prognosis and Long‐Term Outcome of Stenotic Large Vessel Involvement in Giant Cell Arteritis. Arthritis Rheumatol. Published 25 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →