Vasculitis & polymyalgia rheumatica

EULAR recommendations for the management of Behçet’s syndrome: 2025 update

Ann Rheum DisPublished Clinical practice recommendations

Methodological detailsEULAR update, Delphi survey, systematic literature review, levels of evidence and agreement, Task force of 29 members from 11 countries, including 2 patient research partners
  • EULAR update
  • Delphi survey
  • Systematic literature review
  • Levels of evidence and agreement
  • Task force of 29 members from 11 countries, including 2 patient research partners

Recommendations

As issued by the authors

  1. Overarching principles: recognise the relapsing and remitting disease course; individualise treatment according to disease activity and prognostic risk factors; multidisciplinary approach, patient education and shared decision making for optimal care

  2. Mucocutaneous and joint involvement: colchicine is recommended as first-line treatment

  3. Apremilast and immunosuppressives such as TNFα inhibitors are recommended for refractory patients

  4. Organ involvement: more aggressive treatment with GC and immunosuppressives for rapid induction of remission

  5. Early use of monoclonal antibodies against TNFα is encouraged in patients with organ or life-threatening manifestations

Original publication

EULAR recommendations for the management of Behçet’s syndrome: 2025 update. Ann Rheum Dis. Published 23 March 2026. doi:10.1016/j.ard.2026.02.009

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