Vasculitis & polymyalgia rheumatica
Risk of acute myocardial infarction, stroke, and venous thromboembolism among patients with anti-neutrophil cytoplasmic antibody-associated vasculitis in South Korea: A nationwide population-based study
Main finding · Overall cerebro-cardiovascular comorbidities (stroke, acute MI, VTE, PE)Result — go to the resultTimes higher overall risk 2.3Authors' conclusion
This is the first nationwide population-based study to demonstrate a significant risk of cerebro-cardiovascular comorbidities as complications of anti-neutrophil cytoplasmic antibody-associated vasculitis in Korean patients.
Study context
- Population
- Korean patients with newly diagnosed AAV, 2009–2019, nationwide medical claims data1:10 matched controls
- Participants
- 1,905 patients
- Exposure
- Newly diagnosed AAV vs age- and sex-matched controls
- Anti-neutrophil cytoplasmic antibody-associated vasculitisn = 1,905
- Outcome
- Incidence and risk of cerebro-cardiovascular comorbidities (stroke, acute MI, VTE, PE)
Methodological detailsage- and sex-matched controls (1:10), Cox proportional hazards model, medical claims data
- Age- and sex-matched controls (1:10)
- Cox proportional hazards model
- Medical claims data
Main finding
As reported in the abstract
Overall cerebro-cardiovascular comorbidities (stroke, acute MI, VTE, PE)
Times higher overall risk
2.3
- Cerebro-cardiovascular comorbidities occurred in
- 12.6%
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| PE, VTE and strokeAAV vs Controls | aHR (PE) 4.5 |
| PE, VTE and strokeAAV vs Controls | aHR (VTE) 3.1 |
| PE, VTE and strokeAAV vs Controls | aHR (stroke) 2.0 |
Distribution of cerebro-cardiovascular comorbidities in AAV
- Stroke
- 64.6%
- VTE
- 34.6%
- PE
- 18.3%
- Acute MI
- 5.4%
Annual incidence rate of AAV in 2019
- Annual incidence rate
- 0.55 per 100,000 person-years
AAV subtypes
- MPA
- 42.5%
- GPA
- 29.1%
- EGPA
- 28.4%
- Findings similar for each AAV subtype
Original publication
Risk of acute myocardial infarction, stroke, and venous thromboembolism among patients with anti-neutrophil cytoplasmic antibody-associated vasculitis in South Korea: A nationwide population-based study. Joint Bone Spine. Published 21 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →