Sjögren's disease & overlap diseases
Identification of outcome domains in primary Sjögren's disease: A scoping review by the OMERACT Sjögren disease working group
Authors' conclusion
Our scoping review highlighted the heterogeneity of SjD, in the study designs and domains.
Study context
- Population
- RCTs in sjögren's disease (SjD)RCTs, of 5,420 references
- Participants
- 60 rcts
- Outcome
- Outcome domains assessed in RCTs in SjD
Methodological detailssystematic search of Medline (Pubmed) and EMBASE, 2002–March 2023, manual and artificial intelligence (BIBOT) screening, domains mapped to OMERACT 2.1 Filter core areas
- Systematic search of Medline (Pubmed) and EMBASE, 2002–March 2023
- Manual and artificial intelligence (BIBOT) screening
- Domains mapped to OMERACT 2.1 Filter core areas
Main finding
As reported in the abstract
Most frequently assessed domains (proportion of RCTs)
- Perceived dryness (overall dryness)
- 52%
- Fatigue
- 57%
- Pain
- 52%
- Systemic disease activity
- 45%
- Lacrimal gland function
- 47%
- Salivary function
- 55%
- B-cell activation
- 60%
- Health-related quality of life
- 40%
Further findings
Focus of included RCTs
- Overall disease manifestations
- 53%
- Dry eyes
- 17%
- Xerostomia
- 15%
- Fatigue
- 12%
- Pulmonary function
- 3%
Original publication
Identification of outcome domains in primary Sjögren's disease: A scoping review by the OMERACT Sjögren disease working group. Semin Arthritis Rheum. Published 30 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →