Vasculitis & polymyalgia rheumatica
High-resolution computed tomography (HRCT) imaging of pulmonary involvement in granulomatosis with polyangiitis and microscopic polyangiitis at disease onset and during follow-up
Authors' conclusion
Employing a pattern-based approach with HRCT chest scans to assess lung involvement could be valuable in predicting treatment response, relapse, mortality, and could improved the management of AAV patients.
Study context
- Population
- Consecutive unselected AAV patients over 18 with positive ANCA and chest HRCT at diagnosis, Toulouse University Hospital (France), 2004–2019
- Participants
- 157 participants
- Outcome
- Chest HRCT findings (pulmonary involvement) at diagnosis and during follow-up
Methodological detailssingle-centre, consecutive unselected patients, independent review of HRCT by two pulmonologists and one respiratory radiologist
- Single-centre
- Consecutive unselected patients
- Independent review of HRCT by two pulmonologists and one respiratory radiologist
Main finding
As reported in the abstract
Chest HRCT pulmonary involvement at diagnosis
- Pulmonary involvement at diagnosis
- Two-thirds
- Diffuse alveolar hemorrhage (DAH)
- 31.2 %
- Nodules and masses
- 18.5 %
- Bronchial airway involvement
- 13.4 %
- Interstitial involvement
- 12.7 %
Observational data: associations, not effects.
Further findings
Chest HRCT course after induction regimen · two-year period
- Interstitial lung disease (ILD) with progressive course
- half of cases
- Significant improvement in DAH and nodular manifestations
- Bronchial airway involvement variable
Outcomes and survival
- Outcomes and survival rates better for nodular and bronchial involvement
- DAH was the most frequent cause of deaths
Original publication
HRCT imaging of pulmonary involvement in granulomatosis with polyangiitis and microscopic polyangiitis at disease onset and during follow-up. Semin Arthritis Rheum. Published 4 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →