Hospitalization and Mortality Due to Infection Among Children and Adolescents With Systemic Lupus Erythematosus in the United States
Authors' conclusion
Hospitalizations with ICD codes for infection comprised a small proportion of cSLE admissions but accounted for the majority of mortality. The proportion of hospitalizations for infection increased over time. LN and ESRD were risk factors for poor outcomes.
Study context
- Population
- Youth aged 2 to 21 years with International Classification of Diseases (ICD) codes for SLE during admission to US children's hospitals in the Pediatric Health Information System, 2009 to 2021
- Participants
- 8,588 participants26,269 hospitalizations
- Outcome
- Frequency and types of infections in hospitalized children with cSLE; risk factors for ICU admission and mortality
Methodological detailsadministrative database (Pediatric Health Information System), generalized linear mixed effects models
- Administrative database (Pediatric Health Information System)
- Generalized linear mixed effects models
Main finding
As reported in the abstract
Hospitalizations with codes for infection
- Proportion of hospitalizations with infection codes
- 13%
- Increase in proportion over time
- P = 0.04
Observational data: associations, not effects.
Further findings
Risk factors for intensive care unit (ICU) admission among children admitted for serious infection
| OR (95% CI) | ||
|---|---|---|
| LN | 1.47 (1.2–1.8) | |
| ESRD | 2.40 (1.7–3.4) | |
| 0.20.5125Odds ratio (log scale) |
Risk factor for mortality
| OR (95% CI) | ||
|---|---|---|
| ESRD | 2.34 (1.1–4.9) | |
| 0.20.5125Odds ratio (log scale) |
In-hospital mortality
- cSLE hospitalizations for any indication
- 0.4% (n = 103)
- Hospitalizations for infection
- 2% (n = 60)
- Pneumocystis jirovecii pneumonia
- 21%
- Other fungal infections
- 21%
Original publication
Hospitalization and Mortality Due to Infection Among Children and Adolescents With Systemic Lupus Erythematosus in the United States. J Rheumatol. Published 1 April 2024. doi:10.
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