Association of Infant Breastfeeding and Juvenile Spondyloarthritis: A Case-Control Study
Authors' conclusion
This study suggests that infant factors that affect the microbiome may be associated with the occurrence and disease activity of JSpA at presentation.
Study context
- Population
- Children with juvenile spondyloarthritis (JSpA) and age- and sex-matched controls, single centre (mean age 13.0 years; 47.7% female)195 matched pairs
- Comparison
- JSpA cases vs age- and sex-matched controls: infant breastfeeding exposure
- Outcome
- Association of breastfeeding with development of JSpA
Methodological detailssingle-centre, retrospective, age- and sex-matched 1:1, conditional logistic regression
- Single-centre
- Retrospective
- Age- and sex-matched 1:1
- Conditional logistic regression
Main finding
As reported in the abstract
Exposure to breastfeeding of any duration
P < 0.001
Observational data: associations, not effects.
Further findings
Exclusive breastfeeding > 6 months and JSpA development (multivariable)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Exclusive breastfeeding > 6 monthsMultivariable model | 0.47 (0.30–0.72) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | B (95% CI) | P value |
|---|---|---|
| JSpADA6 at presentation and vaginal deliveryLinear regression | −0.65 (−1.13 to −0.17) | P = 0.008 |
JSpADA6 at presentation and breastfeeding > 6 months
- Median JSpADA6 not significantly associated with breastfeeding for > 6 months
Original publication
Association of Infant Breastfeeding and Juvenile Spondyloarthritis: A Case-Control Study. J Rheumatol. Published 1 April 2024. doi:10.
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