Spondyloarthritis & psoriatic arthritis
HLA-B27, axial spondyloarthritis and survival
Authors' conclusion
AS patients, but not nr-axSpA patients, have a significantly shortened life expectancy.
Study context
- Population
- Members of the Swiss ankylosing spondylitis (AS) Patient Society and relatives screened in 1985 for AS/AS/axial spondyloarthritis (axSpA); UK Biobank European-ancestry participantsaxSpA patients analysed
- Participants
- 377 members
- Exposure
- axSpA patients vs matched general population; HLA-B27 carriers vs non-carriers in UK Biobank
- Outcome
- Mortality/life expectancy (SMR); survival by HLA-B27 status
Methodological details35-year follow-up, comparison with matched Swiss population data, UK Biobank population cohort
- 35-year follow-up
- Comparison with matched Swiss population data
- UK Biobank population cohort
Main finding
As reported in the abstract
SMR vs general population
Standardised mortality rate (SMR)
1.37
95% CI 1.11–1.62
AS
SMR
1.38
95% CI 1.11–1.65
HLA-B27-positive AS
SMR
0.44
95% CI 0.23–0.77
nr-axSpA
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality with HLA-B27 carriage, UK Biobank (n=407 480, 30 419 deaths)HLA-B27 carriagevs General populationAdjusted by sex | 1 (0.97–1.1) | P = 0.349 | |
| 0.512Hazard ratio (log scale) |
Mortality with HLA-B27 carriage, UK Biobank (n=407 480, 30 419 deaths)
| HR (95% CI) | P value | ||
|---|---|---|---|
| HLA-B27 carriage (males) | 1 (0.98–1.1) | P = 0.281 | |
| HLA-B27 carriage (females) | 0.96 (0.9–1) | P = 0.232 | |
| 0.512Hazard ratio (log scale) |
| Outcome | SMR (95% CI) |
|---|---|
| SMR in HLA-B27-positive AS by sexHLA-B27-positive AS women vs General population | 1.77 (1.09–2.70) |
| SMR in HLA-B27-positive AS by sexHLA-B27-positive AS men vs General population | 1.31 (1.02–1.59) |
Mortality with HLA-B27 carriage, UK Biobank (n=407 480, 30 419 deaths)
- No increase in vascular disease mortality
Original publication
HLA-B27, axial spondyloarthritis and survival. Ann Rheum Dis. Published 7 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →