Higher prevalence of thyroid-specific autoantibodies (TPOAb and TgAb) is related to a higher prevalence of fractures in females: results from NHANES 2007–2010
Authors' conclusion
Higher prevalence of thyroid-specific autoantibodies may lead to decreased BMD. In females, higher prevalence of TgAb and TPOAb significantly associated with fractures and TPOAb especially relating to the fractures of hip and spine.
Study context
- Population
- Participants of the National Health and Nutrition Examination Survey (2007–2010)392 reported fractures
- Participants
- 3,865 participants
- Exposure
- Thyroid-specific autoantibody positive vs negative participants
- TgAb positiven = 224
- TPOAb positiven = 356
- Outcome
- BMD and fractures (hip, spine or wrist) in relation to thyroid-specific autoantibodies
Methodological detailsbinary logistic regression, univariate screening of candidate variables (P < 0.05)
- Binary logistic regression
- Univariate screening of candidate variables (P < 0.05)
Main finding
As reported in the abstract
- Participants with higher prevalence of TgAb or TPOAb had lower bone mineral density (BMD)
- In females, higher prevalence of TgAb and TPOAb significantly associated with fractures
- In females, TPOAb particularly associated with hip or spine fractures
Observational data: associations, not effects.
Further findings
Fractures in males
- Cigarette use, 25OHD3 and BMD of total femur, femoral neck and total spine significantly associated with fractures
Other factors associated with fractures in females
- Cigarette use and BMD of total femur and femoral neck significantly associated with fractures
Original publication
Higher prevalence of thyroid-specific autoantibodies (TPOAb and TgAb) is related to a higher prevalence of fractures in females: results from NHANES 2007–2010. Osteoporos Int. Published 12 April 2024. doi:10.
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