Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study : Bone fracture and 30-year BMI trajectories
Main finding · All-fracture risk after age 65Result — go to the resultHazard ratio 2.22 95% CI 1.13–4.39Authors' conclusion
This study suggested that people whose BMI slightly increased from normal weight to low-level overweight during 30 years of middle adulthood confer a significantly lower risk of fracture in later life than those whose BMI declined from overweight to normal weight.
Study context
- Population
- Participants of the Framingham Original Cohort Study; BMI trajectories at age 35–64 years, fracture after 65 years292 (16.5%) incident fractures
- Participants
- 1,772 participants
- Exposure
- BMI trajectories over age 35-64 years
- Outcome
- All-fracture risk after age 65
- Follow-up
- average 17.1-year follow-up
Methodological detailslatent class mixed modeling, Cox regression
- Latent class mixed modeling
- Cox regression
Main finding
As reported in the abstract
Hazard ratio
2.22
95% CI 1.13–4.39
Group 1vs Group 4
HR 2.22 (95% CI 1.13–4.39)
Observational data: associations, not effects.
Further findings
Lower extremity fractures (pelvis, hip, leg, foot)
- Similar association pattern
Original publication
Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study : Bone fracture and 30-year BMI trajectories. Osteoporos Int. Published 8 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →