Associations of residential greenness with bone mineral density and osteoporosis: the modifying effect of genetic susceptibility
Authors' conclusion
Residential greenness was associated with higher bone mineral density and decreased risk of incident osteoporosis.
Study context
- Exposure
- Higher vs lower residential greenness
- Outcome
- eBMD, prevalent osteoporosis and incident osteoporosis
Methodological detailslinear regression, logistic regression and Cox proportional hazard models, causal mediation analyses, polygenic risk score joint-effect analysis
- Linear regression, logistic regression and Cox proportional hazard models
- Causal mediation analyses
- Polygenic risk score joint-effect analysis
Main finding
As reported in the abstract
Per IQR increase in NDVI300m
Increase in estimated bone mineral density (eBMD) per IQR increase in NDVI300m
0.0007
95% CI 0.0002 to 0.0013
Prevalent osteoporosis, OR per IQR increase in NDVI300m (95% CI 0.92 to 0.97); 6% lower risk
0.94
Incident osteoporosis, HR per IQR increase in NDVI300m (95% CI 0.93 to 0.98); 5% lower risk
0.95
Observational data: associations, not effects.
Further findings
Joint effects of greenness and Polygenic Risk Score (PRS) on osteoporosis risk
- High Normalised Difference Vegetation Index (NDVI) and low genetic risk vs low NDVI and high genetic risk: lower risk of osteoporosis
- 56% (95% CI 51% to 61%)
- Clear dose-response pattern
Mediators of greenness–incident osteoporosis association
- Primary mediators identified as PM2.5 and NO2
Original publication
Associations of residential greenness with bone mineral density and osteoporosis: the modifying effect of genetic susceptibility. Ann Rheum Dis. Published 11 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →