Lupus & antiphospholipid syndrome
Higher mortality risk from gynaecological neoplasms and non-Hodgkin’s lymphoma in patients with systemic lupus erythematosus: an observational study from the Spanish National Registry
Authors' conclusion
Patients with SLE present a higher risk of death from vulvar neoplasms, cervical carcinomas and B-cell non-Hodgkin's lymphoma in comparison with the general Spanish population.
Study context
- Population
- In-hospital deaths from neoplasms certified in Spain, 2016–2019 (Spanish Hospital Discharge Database)
- Participants
- 139,531 in-hospital neoplasm deaths
- Exposure
- In-hospital neoplasm-related deaths in patients with SLE vs the general Spanish population
- SLEn = 91
- Outcome
- Risk of dying from each neoplasm type and lineage
Methodological detailsobservational, national hospital discharge database, binary logistic regression adjusted for age, female sex, tobacco and alcohol consumption
- Observational
- National hospital discharge database
- Binary logistic regression adjusted for age, female sex, tobacco and alcohol consumption
Main finding
As reported in the abstract
OR
- Solid organ neoplasms: 80.2% vs 91.1%
- 0.393
- Colorectal carcinoma: 1.1% vs 10.8%
- 0.110
- Gynaecological neoplasms: 8.8% vs 3%
- 3.039
- Vulvar neoplasms: 2% vs 0.2%
- 14.767
- Cervical carcinomas: 3.3% vs 0.5%
- 3.809
- Haematological neoplasms: 19.8% vs 8.9%
- 2.546
- non-Hodgkin's lymphoma: 11% vs 2.9%
- 4.060
- B cell lineage non-Hodgkin's lymphoma: 9.9% vs 2.5%
- 4.133
Observational data: associations, not effects.
Original publication
Higher mortality risk from gynaecological neoplasms and non-Hodgkin’s lymphoma in patients with systemic lupus erythematosus: an observational study from the Spanish National Registry. Lupus Sci Med. Published 17 April 2024. doi:10.
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