Lupus & antiphospholipid syndrome
National trends in hospitalisation, in-hospital mortality and resource use for SLE in Spain from 2016 to 2022
Authors' conclusion
SLE-related healthcare episodes increased in Spain from 2016 to 2022, but in-hospital mortality remained stable. SLE episodes involved longer hospital and ICU stays than other episodes.
Study context
- Population
- Healthcare episodes with SLE as principal diagnosis in Spain's National Hospital Discharge Registry, 2016–2022
- Participants
- 24,151 SLE episodes
- Exposure
- SLE episodes vs all other hospitalisation episodes; temporal trends 2016–2022
- SLE episodesn = 24,151
- Outcome
- SLE episodes per year
- Follow-up
- 2016 to 2022
Main finding
As reported in the abstract
- SLE episodes, 2016
- 3002 (6.5/100 000 population)
- SLE episodes, 2022
- 4226 (8.8/100 000 population)
- Increase, p
- p<0.001
Observational data: associations, not effects.
Further findings
Hospital LOS
P < 0.001
ICU stay
P = 0.031
In-hospital mortality · unadjusted comparisons
P < 0.001
In-hospital deaths in individuals aged 15-65 years (proportion of deaths)
P < 0.001
| Outcome | P value |
|---|---|
| In-hospital mortality in SLE episodes by sexMen vs Women · unadjusted comparisons | P < 0.001 |
- In-hospital mortality in SLE episodes by sex: Men 0.7%
- In-hospital mortality in SLE episodes by sex: Women 0.3%
LN episodes · 2016 to 2022
- LN episodes, 2016
- 525 (1.13/100 000 population)
- LN episodes, 2022
- 956 (2.0/100 000 population)
- Increase, p
- P < 0.001
In-hospital mortality
- In-hospital mortality was low and stable
In-hospital mortality in SLE episodes by sex
- More deaths occurred in women
Original publication
National trends in hospitalisation, in-hospital mortality and resource use for SLE in Spain from 2016 to 2022. Lupus Sci Med. Published 24 September 2026. doi:10.
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