Higher Dietary Inflammatory Index and Increased Mortality Rate of Adults With Hyperuricemia: Findings From the National Health and Nutritional Examination Survey (2001–2018)
Main finding · All-cause deathResult — go to the resultHazard ratio 1.18 95% CI 1.03–1.36Authors' conclusion
DII score is found to be positively associated with all-cause and CVD death of adults with hyperuricemia.
Study context
- Population
- Adults with hyperuricemia, National Health and Nutritional Examination Survey 2001–2018
- Participants
- 7,786 adults67,851 person-years
- Exposure
- Higher vs lower Dietary Inflammatory Index (DII) score
- Outcome
- All-cause, CVD and cancer death
Methodological detailsNHANES 2001–2018, linked to National Death Index through December 31, 2019, Cox proportional hazards regression
- NHANES 2001–2018
- Linked to National Death Index through December 31, 2019
- Cox proportional hazards regression
Main finding
All-cause death
Hazard ratio
1.18
95% CI 1.03–1.36
P = 0.01
Higher DIIvs Lower DII
HR 1.18 (95% CI 1.03–1.36); P = 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CVD deathHigher DIIvs Lower DIIAdjusted | 1.30 (1.03–1.63) | P = 0.02 | |
| All-cause death per one-unit increment in DII (continuous) | 1.05 (1.01–1.08) | ||
| CVD death per one-unit increment in DII (continuous) | 1.08 (1.02–1.15) | ||
| 0.512Hazard ratio (log scale) |
- Cardiovascular disease (CVD) death: 532 CVD deaths
Cancer death
- 246 cancer deaths
All-cause death by sex (subgroup)
- Association between DII score and all-cause death more significant in males
Original publication
Higher Dietary Inflammatory Index and Increased Mortality Rate of Adults With Hyperuricemia: Findings From the National Health and Nutritional Examination Survey (2001–2018). Arthritis Care Res (Hoboken). Published 2 May 2024. doi:10.
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