Lupus & antiphospholipid syndrome
High-sensitivity serum interferon-α and interferon-γ as immunometabolic mediators of metabolic syndrome in systemic lupus erythematosus
Authors' conclusion
Serum IFN-α and IFN-γ are independently associated with key components of metabolic syndrome in SLE, including dyslipidaemia and pancreatic β-cell dysfunction.
Study context
- Population
- Patients with SLE
- Participants
- 313 patients
- Outcome
- Associations of serum IFN-α and IFN-γ with lipid profile and insulin resistance indices
Methodological detailsmultivariable linear regression, single molecule array (ultrasensitive)
- Multivariable linear regression
- Single molecule array (ultrasensitive)
Main finding
As reported in the abstract
- IFN-α: significant positive associations with triglycerides, LDL cholesterol, lipoprotein(a) and atherogenic index; negative association with HDL cholesterol; remained significant after adjustment for IFN-γ
- IFN-γ: significant positive association with triglycerides and pancreatic β-cell dysfunction, after adjustment for covariates incl. serum IFN-α
- Multivariable adjustment
Observational data: associations, not effects.
Original publication
High-sensitivity serum interferon-α and interferon-γ as immunometabolic mediators of metabolic syndrome in systemic lupus erythematosus. Rheumatology (Oxford). Published 26 April 2026. doi:10.
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