Lupus & antiphospholipid syndrome
High sensitivity measurement of circulating interferon proteins in systemic lupus erythematosus
Authors' conclusion
Plasma levels of type I IFN proteins (IFNα1: IFNα13, IFNα2 and IFNω but not IFNβ) and type III IFN proteins (IFNλ1, IFNλ2:IFNλ3) were increased in active disease groups and ISG scores recapitulated this.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE)
- Participants
- 266 SLE patients
- Exposure
- SLE patients vs healthy controls; IFN profiles by 95th percentile threshold in healthy controls
- SLEn = 266
- Outcome
- Plasma levels of seven IFN proteins (type I: IFNα1:IFNα13, IFNα2, IFNβ, IFNω; type II: IFNγ; type III: IFNλ1, IFNλ2:IFNλ3) and their relationship to disease activity and type I ISG scores
Methodological detailshigh sensitivity assay (NULISAseq Inflammation Panel 250), comparison with healthy controls
- High sensitivity assay (NULISAseq Inflammation Panel 250)
- Comparison with healthy controls
Main finding
As reported in the abstract
IFN profile: high type I+III
35%, n=93
IFN profile: normal levels of all IFN proteins
25%, n=67
IFN profile: high type I only
21%, n=56
IFN profile: high type I+II+III
13%, n=34
Observational data: associations, not effects.
Original publication
High sensitivity measurement of circulating interferon proteins in systemic lupus erythematosus. Clin Exp Rheumatol. Published 1 May 2025. doi:10.
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