Lupus & antiphospholipid syndrome
Health‐Related Quality of Life in Adults With Adolescent‐ and Adult‐Onset Systemic Lupus Erythematosus: A Longitudinal Study of a Multiethnic US Cohort
Authors' conclusion
Adults with adolescent-onset SLE exhibited better physical functioning than those in the adult SLE group, despite more severe disease; noteworthy, HRQoL was below the general US population, despite clinically meaningful improvement in HRQoL over time in both groups.
Study context
- Population
- Adult systemic lupus erythematosus (SLE) patients enrolled in the LUpus in MInorities: NAture versus Nurture cohort
- Participants
- 470 patients
- Exposure
- Adolescent-onset SLE vs adult-onset SLE
- Adolescent-onset SLEn = 95
- Adult-onset SLEn = 375reference
- Outcome
- Longitudinal trajectories of SF-36 physical component summary (PCS) and mental component summary (MCS) scores
Methodological detailsmultiethnic US cohort (LUMINA), linear mixed model
- Multiethnic US cohort (LUMINA)
- Linear mixed model
Main finding
As reported in the abstract
Last mean physical component summary (PCS) score, adolescent-onset SLE
43.9
Last mean mental component summary (MCS) score, adolescent-onset SLE
45.3
Last mean PCS score, adult-onset SLE
38.1
Last mean MCS score, adult-onset SLE
43
Observational data: associations, not effects.
Further findings
| Outcome | Adolescent-onset SLE | Adult-onset SLE | P value |
|---|---|---|---|
| Baseline SF-36 PCS score (higher = better physical functioning) | 38.9 | 34.3 | P < 0.001 |
| Baseline SF-36 MCS score | 41.4 | 40.5 | P = 0.53 |
Original publication
Health‐Related Quality of Life in Adults With Adolescent‐ and Adult‐Onset Systemic Lupus Erythematosus: A Longitudinal Study of a Multiethnic US Cohort. Arthritis Care Res (Hoboken). Published 30 January 2023. doi:10.
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