Health Perceptions, Multimorbidity, and New Fractures and Mortality Among Patients With a Fracture
Authors' conclusion
In this cohort study, both CCI and SRH measures were associated with increased risk of subsequent fractures and mortality after fracture
Study context
- Population
- Adults with incident fracture in the Sax Institute's 45 and Up Study, New South Wales, Australia; recruited July 2005–December 2009, followed to April 201716,191 female, 9089 male
- Participants
- 25,280 adults
- Exposure
- Charlson Comorbidity Index (CCI) score 2 to 3 and ≥4 vs CCI <2; SRH categories
- Outcome
- Subsequent fracture or mortality after an incident fracture
Methodological detailsstratified by sex, linked hospital admission and medication records
- Stratified by sex
- Linked hospital admission and medication records
Main finding
As reported in the abstract
median follow-up 2.8 years (IQR, 1.1-5.2 years)
Each group vs CCI <2Hazard ratio (95% CI)
CCI 2-3Subsequent fracture, females
1.16(1.05–1.27)
CCI 2-3Subsequent fracture, males
1.25(1.09–1.43)
CCI 2-3Mortality, females
2.19(1.99–2.40)
CCI 2-3Mortality, males
1.89(1.71–2.09)
CCI ≥4Subsequent fracture, females
1.33(1.12–1.58)
CCI ≥4Subsequent fracture, males
1.48(1.21–1.81)
CCI ≥4Mortality, females
4.48(3.97–5.06)
CCI ≥4Mortality, males
3.82(3.41–4.29)
Observational data: associations, not effects.
Further findings
- SRH significantly associated with subsequent fracture and mortality; poorest health and quality of life had highest subsequent fracture risks and even higher mortality risks
Original publication
Health Perceptions, Multimorbidity, and New Fractures and Mortality Among Patients With a Fracture. JAMA Netw Open. Published 1 April 2024. doi:10.
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