Gut microbiome and intestinal inflammation in preclinical stages of rheumatoid arthritis
Authors' conclusion
We could not identify microbiome profiles associated with preclinical stages of RA.
Study context
- Population
- First-degree relatives of patients with rheumatoid arthritis (RA) (RA-FDRs) from the SCREEN-RA cohort
- Participants
- 371 relatives
- Exposure
- Preclinical stages of RA among RA-FDRs: controls vs high genetic risk vs autoimmunity vs symptomatic
- Outcome
- Quantitative microbiome profiles by preclinical stage of RA
Methodological detailsquantitative microbiome profiling, 16S sequencing
- Quantitative microbiome profiling
- 16S sequencing
Main finding
As reported in the abstract
Quantitative microbiome profiles by preclinical stage
- No significant differences in quantitative microbiome profiles by preclinical stages (permutational multivariate analysis of variance (PERMANOVA), R2=0.00798)
- p=0.56
Observational data: associations, not effects.
Further findings
Relative microbiome profiles
- Similar results (PERMANOVA, R2=0.0073)
- P = 0.83
- Similar results with Aldex2 on 16S sequence counts
Faecal calprotectin
- No differences between groups
- P = 0.3
Original publication
Gut microbiome and intestinal inflammation in preclinical stages of rheumatoid arthritis. RMD Open. Published 30 January 2024. doi:10.
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