Gout and Excess Risk of Severe SARS–CoV‐2 Infection Among Vaccinated Individuals: A General Population Study
Authors' conclusion
These general population data suggest that individuals with gout, especially women, have higher risks of SARS-CoV-2 infection and severe outcomes, even when vaccinated.
Study context
- Population
- General population, The Health Improvement Network, UK, followed from December 8, 2020 to October 31, 2021; vaccinated and unvaccinated cohortsvaccinated cohort
- Participants
- 54,576 vs 1,336,377
- Exposure
- Individuals with gout vs those without gout, by SARS-CoV-2 vaccination status
- Goutn = 54,576
- Without goutn = 1,336,377reference
- Outcome
- SARS-CoV-2 (breakthrough) infection and severe outcomes (hospitalization and death within 30 days after infection)
Methodological details2 cohort studies, overlap weighting of exposure scores, Cox proportional hazards model
- 2 cohort studies
- Overlap weighting of exposure scores
- Cox proportional hazards model
Main finding
As reported in the abstract
Breakthrough COVID-19 infection (vaccinated cohort)
- Partially adjusted rate difference (RD) of breakthrough infection, gout vs without gout
- 0.91 cases per 1,000 person-months (95% CI 0.62-1.20 cases per 1,000 person-months)
- Partially adjusted HR of breakthrough infection, gout vs without gout
- 1.24 (95% CI 1.19-1.30)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Hospitalization, vaccinated cohort · within 30 days after infection | 1.30 (1.10–1.53) | |
| Death, vaccinated cohort · within 30 days after infection | 1.36 (0.87–2.13) | |
| Hospitalization in women (subgroup) | 1.55 (1.15–2.10) | |
| Death in women (subgroup) | 2.46 (1.12–5.41) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Unvaccinated cohort
- Similar associations with gout were observed in the unvaccinated cohort
Original publication
Gout and Excess Risk of Severe SARS–CoV‐2 Infection Among Vaccinated Individuals: A General Population Study. Arthritis Rheumatol. Published 30 November 2022. doi:10.
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