Associations Between Low Serum Urate, Body Composition, and Mortality
Authors' conclusion
Sarcopenia and weight loss are more common among patients with low serum UA concentrations. Differences in body composition may help to explain associations between low levels of serum UA and higher mortality.
Study context
- Population
- NHANES (1999–2006) participants with whole-body DXA body composition measurements and serum UA concentrations
- Participants
- 13,979 participants
- Exposure
- Low serum UA vs normal serum UA
- Outcome
- Association of low serum UA with sarcopenia (body composition) and with mortality before and after adjustment for body composition
Methodological detailsNHANES 1999-2006, logistic regression, Cox proportional hazards regression, adjustment for body composition
- NHANES 1999-2006
- Logistic regression
- Cox proportional hazards regression
- Adjustment for body composition
Main finding
As reported in the abstract
Low ALMI Z scores (low lean mass)
P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality, before adjustment for body composition | 1.61 (1.14–2.28) | P = 0.008 | |
| Mortality, after adjustment for body composition and weight lossAttenuated and not significant | 1.30 (0.92–1.85) | P = 0.13 | |
| 0.512Hazard ratio (log scale) |
Original publication
Associations Between Low Serum Urate, Body Composition, and Mortality. Arthritis Rheumatol. Published 28 November 2022. doi:10.
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