Vasculitis & polymyalgia rheumatica
Genome‐Wide DNA Methylation Study Reveals Specific Signatures in the Affected Arterial Tissue of Patients With Giant Cell Arteritis
Authors' conclusion
Our study identified GCA-specific DNA methylation signatures in arterial tissue, revealing disrupted inflammatory and vascular pathways and suggesting the involvement of exhausted T cells in this condition.
Study context
- Population
- Temporal artery biopsy samples from patients with giant cell arteritis (GCA) and controls
- Participants
- 79 temporal artery biopsy samples
- Comparison
- GCA vs controls
- GCAn = 69
- Controlsn = 10reference
- Outcome
- DNA methylation signatures in GCA-affected arterial tissue
Methodological detailsepigenome-wide association study
- Epigenome-wide association study
Main finding
As reported in the abstract
Differentially methylated positions (DMPs) (Padj < 0.05, |Δβ| > 0.3)
3,644
Potentially dysregulated genes annotated to DMPs
1,517
Additional genes identified by annotation of significant differentially methylated regions (DMRs)
282
Genes consistently affected across omics datasets, many linked to immune signaling and T cell regulation
37
Original publication
Genome‐Wide DNA Methylation Study Reveals Specific Signatures in the Affected Arterial Tissue of Patients With Giant Cell Arteritis. Arthritis Rheumatol. Published 11 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →