Vasculitis & polymyalgia rheumatica
Efficacy and tolerability of switching from coated to compressed colchicine preparations in patients with Behçet’s syndrome
Authors' conclusion
Switching between colchicine preparations seems to be a safe and effective option for BS patients, providing good drug survival rates, patient and physician global scores, and activity scores.
Study context
- Population
- Behçet's syndrome (BS) patients with mucocutaneous and/or joint involvement with inadequate response to or intolerance of coated colchicine, switched to compressed colchicine 2017–202329 women (64.4%)
- Participants
- 45 patients
- Exposure
- Switch from coated to compressed colchicine preparation; final visit vs baseline
- Outcome
- Endpoints: disease activity by BDCAI, patients' and physicians' global VAS (10 cm), and CRP
Methodological detailsretrospective chart review, single-group before–after comparison
- Retrospective chart review
- Single-group before–after comparison
Main finding
As reported in the abstract
final visit vs baseline
- Still on compressed colchicine during mean follow-up of 32.2 (27) months
- 30 patients (65.2%)
- Patients' global visual analogue scale (VAS), baseline vs final visit
- 5.8 (2.3) vs 3.7 (3.3); P = 0.008
- Physicians' global VAS, baseline vs final visit
- 4.2 (2.1) vs 2.3 (2.7); P = 0.003
- C-reactive protein (CRP), baseline vs final visit
- 7.2 (10.4) vs 3.6 (5.2); P = 0.039
- Mean Behçet's Disease Current Activity Index (BDCAI), baseline vs final visit
- 2.6 (1.10) vs 2.04 (1.24); P = 0.006
Observational data: associations, not effects.
Further findings
Discontinuation due to inefficacy
- Patients discontinued due to inefficacy
- 6
Safety
Discontinuation due to adverse events
- Patients discontinued due to adverse events
- 7
Original publication
Efficacy and tolerability of switching from coated to compressed colchicine preparations in patients with Behçet’s syndrome. Rheumatology (Oxford). Published 8 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →