Lupus & antiphospholipid syndrome
Feto-maternal outcomes of pregnancies in women with SLE: Experience from a tertiary care center of Asia
Authors' conclusion
Planned pregnancy and less severe disease flares during pregnancy is associated with more favorable feto-maternal outcomes.
Study context
- Population
- Pregnant patients with SLE diagnosed and delivered at Aga khan university hospital, Karachi, Jan 1998 to Dec 2019
- Outcome
- Maternal and fetal complications in pregnancies with SLE
Methodological detailsretrospective record review, single-centre, matched case-control comparison
- Retrospective record review
- Single-centre
- Matched case-control comparison
Main finding
As reported in the abstract
Adverse maternal and perinatal outcomes
- Pre-eclampsia
- 28.8%
- Eclampsia
- 3.2%
- Cesarean section
- 57.6%
- Thrombocytopenia
- 9.6%
- Intrauterine growth retardation
- 24%
- Preterm birth <34 weeks
- 19.2%
- Preterm birth <37 weeks
- 63.2%
- APGAR Score < 7 at 1 min
- 5.6%
- Neonatal death
- 5.6%
Observational data: associations, not effects.
Further findings
SLE disease activity during pregnancy (SLEDAI-2K)
- Mild disease activity
- 25.6%
- Moderate disease activity
- 25.6%
- Flare up in third trimester
- 51.7%
High-risk vs low-risk APS patients
- High-risk patients
- 42
- Positive IgG
- 88%
- Positive IgM
- 83.3%
- Lupus anticoagulant
- 33.3%
Original publication
Feto-maternal outcomes of pregnancies in women with SLE: Experience from a tertiary care center of Asia. Lupus. Published 16 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →