Sjögren's disease & overlap diseases
Fetal–neonatal and maternal outcomes in women with Sjögren syndrome: a population-based registry linkage study
Authors' conclusion
Women with SS have significant risks of adverse fetal-neonatal and maternal outcomes
Study context
- Population
- Pregnancies between 2004 and 2014, Taiwan National Health Insurance database and birth registry
- Participants
- 2,100,143 pregnancies
- Exposure
- Pregnancies in women with sjögren syndrome (SS) vs without SS
- SSn = 449
- Non-SSn = 2,099,694reference
- Outcome
- Fetal-neonatal and maternal outcomes
Methodological detailsTaiwan National Health Insurance database and birth registry linkage
- Taiwan National Health Insurance database and birth registry linkage
Main finding
As reported in the abstract
Fetal-neonatal outcomes
SS vs Non-SSOdds ratio (95% CI)
Stillbirth
2.14(1.01–4.55)
Low birth weight (<2500 g)
2.53(1.92–3.33)
Small for gestational age
2.03(1.57–2.03)
Fetal distress
1.72(1.2–2.45)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Maternal outcomesSSvs Non-SSPulmonary oedema | 11.64 (1.62–83.48) | |
| Maternal outcomesSSvs Non-SSShock | 6.07 (1.51–24.3) | |
| Maternal outcomesSSvs Non-SSRespiratory distress | 5.61 (1.39–22.6) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Fetal–neonatal and maternal outcomes in women with Sjögren syndrome: a population-based registry linkage study. Rheumatology (Oxford). Published 5 January 2023. doi:10.
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