Lupus & antiphospholipid syndrome
Factors predictive of severe thrombocytopenia and its impact on poor outcomes in Latin American patients with systemic lupus erythematosus: Data from a multiethnic Latin American cohort
Authors' conclusion
Severe thrombocytopenia occurs during the early course of SLE. Mestizo ethnicity and AIHA at baseline emerged as independent predictors of a shorter time to severe thrombocytopenia occurrence while a middle/high socioeconomic status seems to be protective against its occurrence. Damage and mortality did not seem to be impacted by the occurrence of severe thrombocytopenia.
Study context
- Population
- SLE patients from a multiethnic Latin American cohortmean (SD) follow-up 5.9 (3.6) years
- Participants
- 1,217 patients
- Outcome
- Time to severe thrombocytopenia (platelet count ≤20,000/mm³) from onset of SLE symptoms; predictors and impact on damage and mortality
Methodological detailsmultiethnic, multicentre, Cox proportional hazards regression, logistic regression, negative binomial regression
- Multiethnic
- Multicentre
- Cox proportional hazards regression
- Logistic regression
- Negative binomial regression
Main finding
As reported in the abstract
Predictors of time to severe thrombocytopenia (multivariable)
Hazard ratio (95% CI)P value
Mestizo ethnicityshorter time to severe thrombocytopenia
2.67(1.12–6.37)
P = 0.027AIHA at baselineshorter time to severe thrombocytopenia
3.99(1.05–15.19)
P = 0.042Middle/high socioeconomic statuslonger time to severe thrombocytopenia
0.23(0.08–0.69)
P = 0.008- Developed severe thrombocytopenia
- 33 (2.7%)
- Median time from SLE symptom onset to severe thrombocytopenia, months (IQR 8.7-62.0)
- 22
Observational data: associations, not effects.
Further findings
Ethnicity of patients with severe thrombocytopenia
- Mestizo
- 60.6%
- Caucasian
- 27.3%
- African Latin American
- 12.1%
Impact of severe thrombocytopenia on damage and mortality
- Severe thrombocytopenia contributed neither to damage nor to mortality
Original publication
Factors predictive of severe thrombocytopenia and its impact on poor outcomes in Latin American patients with systemic lupus erythematosus: Data from a multiethnic Latin American cohort. Semin Arthritis Rheum. Published 11 October 2024. doi:10.
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