Lupus & antiphospholipid syndrome
Factors associated with non-adherence to medications in systemic lupus erythematosus: Results from a Swedish survey
Authors' conclusion
Beliefs about medications were a major determinant of medication non-adherence.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) from Karolinska and Örebro University Hospitals, Sweden (median age 52.0 years; 86.3% women)
- Participants
- 205 respondents
- Outcome
- Determinants of medication non-adherence (<80% on CQR-19 or MASRI)
Methodological detailssurvey-based, multivariable logistic regression adjusted for age, sex, disease activity and organ damage
- Survey-based
- Multivariable logistic regression adjusted for age, sex, disease activity and organ damage
Main finding
As reported in the abstract
Factors associated with medication non-adherence
- Non-adherent to medications (CQR-19)
- 66.8%
- Non-adherent to antimalarial agents (AMA) (MASRI)
- 6.6%
- Non-adherent to GC (MASRI)
- 6.3%
- Positive beliefs about GC vs non-adherence to GC, OR
- 0.77 (95% CI 0.59-0.99; p = .039)
- Positive beliefs about medications overall vs non-adherence to GC, OR
- 0.71 (95% CI 0.52-0.97; p = .029)
- Anxiety/depression vs non-adherence (CQR-19), OR
- 3.09 (95% CI 1.12-8.54; p = .029)
- Medication concerns vs non-adherence (CQR-19), OR
- 1.12 (95% CI 1.05-1.20; p < .001)
- Belief medications are overused vs non-adherence (CQR-19), OR
- 1.30 (95% CI 1.15-1.46; p < .001)
- Belief medications are harmful vs non-adherence (CQR-19), OR
- 1.36 (95% CI 1.19-1.56; p < .001)
- Beliefs in necessity of medications vs non-adherence (CQR-19), OR
- 0.73 (95% CI 0.65-0.82; p < .001)
- Positive beliefs in medications vs non-adherence (CQR-19), OR
- 0.72 (95% CI 0.60-0.86; p < .001)
Observational data: associations, not effects.
Original publication
Factors associated with non-adherence to medications in systemic lupus erythematosus: Results from a Swedish survey. Lupus. Published 28 March 2024. doi:10.
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