Lupus & antiphospholipid syndrome
Occurrence of venous thromboembolism in SLE: findings from a nationwide cohort and a clinical cohort in Sweden
Main finding · Incident VTE, nationwide cohortResult — go to the resultHazard ratio 3.3 95% CI 2.9–3.8Authors' conclusion
SLE is associated with an over threefold increased risk of VTE, in particular soon after SLE diagnosis, underscoring the need for individualised VTE risk assessment.
Study context
- Population
- Newly diagnosed patients with SLE (nationwide cohort, Sweden) and established patients with SLE at Karolinska University Hospital (mean age 49 years; 83% female in nationwide cohort)nationwide cohort
- Participants
- 4,335 participants
- Exposure
- SLE vs matched general population comparators
- SLEn = 4,335
- Outcome
- Incident VTE
Methodological detailsnationwide register-based, matched on age, sex and residence, Cox models, flexible parametric survival models
- Nationwide register-based
- Matched on age, sex and residence
- Cox models
- Flexible parametric survival models
Main finding
Incident VTE, nationwide cohort
Hazard ratio
3.3
95% CI 2.9–3.8
By group
SLEvs Comparators
HR 3.3 (95% CI 2.9–3.8)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident VTE, Karolinska cohort (N=784) | 4.9 (3.7–6.5) | |
| 0.10.31310Hazard ratio (log scale) |
Venous thromboembolism (VTE) risk over time
- VTE risk highest in the first few years after SLE diagnosis
VTE by lupus nephritis (LN) and aPL positivity (Karolinska cohort)
- aPL positivity associated with a higher hazard (non-significant; attenuated after excluding prior VTE)
- 60%
- LN not significantly associated with VTE
Original publication
Occurrence of venous thromboembolism in SLE: findings from a nationwide cohort and a clinical cohort in Sweden. Lupus Sci Med. Published 6 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →