Spondyloarthritis & psoriatic arthritis
Factors associated with long-term opioid use among patients with axial spondyloarthritis or psoriatic arthritis who initiate opioids
Study context
- Population
- Adults with axSpA or psoriatic arthritis (PsA) without prior cancer who initiated opioids between 2006 and 2021, UK primary care10,300 opioid initiations
- Participants
- 8,212 adults
- Outcome
- Long-term opioid use (≥3 opioid prescriptions within 90 days, or ≥90 days of opioid supply)
- Follow-up
- First year
Methodological detailsnational UK primary care database (CPRD Gold), mixed-effects logistic regression with patient-level random intercept
- National UK primary care database (CPRD Gold)
- Mixed-effects logistic regression with patient-level random intercept
Main finding
As reported in the abstract
Factors associated with long-term opioid use
Odds ratio (95% CI)
Current smoker
1.62(1.38,1.90)
Substance use disorder
2.34(1.05,5.21)
History of suicide/self-harm
1.84(1.13,2.99)
Co-existing FM
1.62(1.11,2.37)
High Charlson Comorbidity Indexfor high scores
3.61(1.69,7.71)
High MME/day at initiation
1.03(1.02,1.03)
Gabapentinoid use
2.35(1.75,3.16)
Antidepressant use
1.69(1.45,1.98)
Observational data: associations, not effects.
Original publication
Factors associated with long-term opioid use among patients with axial spondyloarthritis or psoriatic arthritis who initiate opioids. Rheumatology (Oxford). Published 16 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →