Factors associated with fatigue in children with enthesitis/spondylitis-related juvenile idiopathic arthritis: an exploratory cross-sectional study
Authors' conclusion
Fatigue in children with ESR-JIA was associated with multiple psychological and physical factors. Lower muscle mass, weaker ankle plantarflexor strength, higher pain intensity, depression-related cognitive changes, and poorer sleep efficiency were associated with more severe fatigue.
Study context
- Population
- Children diagnosed with enthesitis/spondylitis-related JIA (enthesitis/spondylitis-related juvenile idiopathic arthritis (ESR-JIA))
- Participants
- 77 children
- Outcome
- Fatigue (PedsQL-MFS total score; higher scores indicate less fatigue) and its associated factors
Methodological detailsexploratory
- Exploratory
Main finding
As reported in the abstract
Factors independently associated with PedsQL-MFS total score (stepwise multivariable linear regression)
Pain intensity, depression-related cognitive changes, ankle plantarflexion strength and sleep efficiency independently associated with PedsQL-MFS total scores; variance explained
33.6%
Observational data: associations, not effects.
Further findings
Univariable linear regression: factors associated with PedsQL-MFS total score
- Body composition (free fat mass, skeletal muscle mass, skeletal muscle index) and muscle strength (ankle dorsiflexion and plantarflexion strength) positively correlated with PedsQL-MFS total scores
- Pain intensity, depression-related symptoms and sleep efficiency negatively associated with PedsQL-MFS total scores
Original publication
Factors associated with fatigue in children with enthesitis/spondylitis-related juvenile idiopathic arthritis: an exploratory cross-sectional study. Pediatr Rheumatol Online J. Published 17 July 2026. doi:10.
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