Lupus & antiphospholipid syndrome
Exploring the association between preeclampsia and antiphospholipid antibodies. A prospective study
Main finding · aPL positivityResult — go to the resultOdds ratio 4.63 95% CI 1.523–14.107Authors' conclusion
These results suggest that the presence of aPL is associated to severe PE. The positivity of aPL is associated to severity of PE, independently from gestational age.
Study context
- Population
- Pregnant women with severe preeclampsia (PE) and normal pregnant controls
- Participants
- 140 women
- Exposure
- Severe preeclampsia vs normal pregnancy (healthy controls); early vs late severe preeclampsia
- Controln = 40reference
- SGn = 100
- Outcome
- aPL positivity (association between aPL and severe PE)
Methodological detailsinterventional
- Interventional
Main finding
aPL positivity
Odds ratio
4.63
95% CI 1.523–14.107
P = 0.005
Events by group
SGvs Control
OR 4.63 (95% CI 1.523–14.107); P = 0.005
As reported in the abstract
Observational data: associations, not effects.
Further findings
aPL positivity in late severe PE
| OR (95% CI) | P value | ||
|---|---|---|---|
| Late severe PE | 5.0 (1.4901–16.777) | P = 0.008 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value |
|---|---|---|
| aPL positivity in early severe PE (<34 weeks) | 4384 (1.3615–14.1206) | P = 0.01 |
Original publication
Exploring the association between preeclampsia and antiphospholipid antibodies. A prospective study. Lupus. Published 24 December 2025. doi:10.
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